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Caspase-6 (7O3) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37103
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  • 种属：H，M，R
  • 用途：WB，FCM，IP，IHC-P，IF-P，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37103
  • 别名
    Apoptotic protease Mch-2; CASP-6; CASP6; Caspase 6; Caspase 6 apoptosis related cysteine protease; Caspase 6, apoptosis related cysteine peptidase; Caspase-6; Caspase-6 subunit p11; Mch2
  • 产品名称
    Caspase-6 (7O3) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    CASP6
  • 蛋白名称
    MCH2
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-ICC,FCM
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    839
  • Human Swissprot No.
    P55212
  • 免疫原
    A synthetic peptide of human Caspase-6
  • 稀释度
    WB 1:2000-1:20000, IHC-P/IF-P 1:100-1:200, IF-ICC 1:100-1:200, FCM 1:200-1:1000
  • 参考分子量
    11kDa(cleavage),33kDa
  • 预测分子量
    33kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Caspase-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 细胞定位
    Cytoplasm.
  • 功能
    Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed:8663580, PubMed:32298652). During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:17401638, PubMed:8663580, PubMed:9463409). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (PubMed:10559921, PubMed:14657026). Cleaves phospholipid scramblase proteins XKR4 and XKR9 (By similarity). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses (PubMed:32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed:32298652).
  • 纯度
    Affinity-chromatography
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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