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CD163 (11A14) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37119
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  • 种属：H
  • 用途：WB，IHC-P，IF-P
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37119
  • 别名
    CD163; SCARI1; sCD163
  • 产品名称
    CD163 (11A14) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    CD163
  • 蛋白名称
    M130
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    9332
  • Human Swissprot No.
    Q86VB7
  • 免疫原
    Recombinant protein of human CD163
  • 稀释度
    WB 1:1000, IHC-P/IF-P 1:200-1:500
  • 参考分子量
    150kDa
  • 预测分子量
    126kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    CD163 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood
  • 细胞定位
    [Soluble CD163]: Secreted
  • 功能
    Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
  • 纯度
    Affinity-chromatography
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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