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RSK1 p90 (Phospho T573) (14Q4) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37164
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  • 种属：H
  • 用途：WB，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37164
  • 纯度
    Affinity-chromatography
  • 别名
    HU1; MAPKAPK1A; p90rsk; p90RSK1; p90S6K; pp90RSK1; Ribosomal protein S6 kinase alpha 1; Ribosomal S6 kinase 1; RPS6K1; rps6ka; Rps6ka1; RSK; RSK1; S6K alpha 1
  • 产品名称
    RSK1 p90 (Phospho T573) (14Q4) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    RPS6KA1
  • 蛋白名称
    MAPKAPK1A, RSK1
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-ICC
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    6195
  • Human Swissprot No.
    Q15418
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Thr573 of human RSK1 p90
  • 稀释度
    WB 1:1000, IF-ICC 1:100-1:500
  • 参考分子量
    90kDa
  • 预测分子量
    83kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-RSK1 p90 (T573) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 细胞定位
    Nucleus. Cytoplasm.
  • 功能
    Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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