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Chk2 (Phospho S33 + S35) (9G17) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37168
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  • 种属：H
  • 用途：WB
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37168
  • 纯度
    Affinity-chromatography
  • 别名
    Cds1; Checkpoint kinase 2; Chek2; hCds1; LFS2; RAD53; Serine/threonine protein kinase Chk2
  • 产品名称
    Chk2 (Phospho S33 + S35) (9G17) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    CHEK2
  • 蛋白名称
    CDS1, CHK2, RAD53
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    11200
  • Human Swissprot No.
    O96017
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Ser33/Ser35 of human Chk2
  • 稀释度
    WB 1:1000
  • 参考分子量
    61kDa
  • 预测分子量
    61kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-Chk2 (S33 + S35) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues
  • 细胞定位
    [Isoform 2]: Nucleus. Note=Isoform 10 is present throughout the cell [Isoform 7]: Nucleus. [Isoform 12]: Nucleus.
  • 功能
    Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK- cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978).
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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