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PP2A α/β (1I10) Rabbit Monoclonal Antibody  Cite:0    分享
抗体类满2送1  

货号： IM68713
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  • 种属：H，M，R
  • 用途：WB，ELISA，IP，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM68713
  • 别名
    PP2A A;PP2A alpha;PP2A B;PP2A beta;PP2A-alpha;PP2A-beta;PP2AA_HUMAN;PP2Aalpha;PP2AB_HUMAN;PP2Abeta;PP2Ac;PP2CA;PP2Calpha;PP2CB;PPP2CA;PPP2CB;Protein phosphatase 2 catalytic subunit alpha isoform;Protein phosphatase 2 catalytic subunit beta isoform;Protein phosphatase type 2A catalytic subunit;Replication protein C;RP C;RP-C;RPC;Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine protein phosphatase 2A catalytic subunit beta isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PPP2CB
  • 产品名称
    PP2A α/β (1I10) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    PPP2CA
  • 蛋白名称
    Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PP2A-beta;PP2A-alpha;Replication protein C;RP-C.
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • Human Gene ID
    5515;5516
  • Human Swissprot No.
    P67775,P62714
  • Mouse Gene ID
    19052;19053
  • Mouse Swissprot No.
    P63330;P62715
  • Rat Gene ID
    24672;24673
  • Rat Swissprot No.
    P63331;P62716
  • 稀释度
    IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
  • 参考分子量
    36kDa
  • 预测分子量
    36kDa
  • 宿主
    Rabbit
  • 同种型
    Monoclonal, rabbit, IgG, Kappa
  • 背景介绍
    This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008],
  • 信号通路
    Oocyte meiosis;WNT;WNT-T CELLTGF-beta;Tight junction;Long-term depression
  • 功能
    PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.
  • 纯化
    Protein A
储存与保存

1.保存：-20℃

2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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