产品货号

IM68726

别名

Transcription factor AP-1 (Activator protein 1;AP1;Proto-oncogene c-Jun;V-jun avian sarcoma virus 17 oncogene homolog;p39)

产品名称

c-Jun (2S8) Rabbit Monoclonal Antibody

类别

抗体产品

基因名称

JUN

蛋白名称

C-Jun (Hydroxylated-p244); Transcription factor AP-1;jun;c-jun；AP-1

Clonality

Monoclonal

推荐应用

WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA

反应种属

Human,Mouse,Rat

存储缓冲液

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Human Gene ID

3725

Human Swissprot No.

P05412

Mouse Gene ID

16476

Mouse Swissprot No.

P05627

Rat Gene ID

24516

Rat Swissprot No.

P17325

稀释度

IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200

参考分子量

43kDa

预测分子量

36kDa

宿主

Rabbit

同种型

Monoclonal, rabbit, IgG, Kappa

背景介绍

function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.

功能

protein import into nucleus, translocation, response to reactive oxygen species, angiogenesis, blood vessel development, release of cytochrome c from mitochondria, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, vasculature development, response to molecule of bacterial origin,regulation of myeloid leukocyte differentiation, positive regulation of myeloid leukocyte differentiation, regulation of DNA replication, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein targeting, protein import into nucleus, cellular ion homeostasis, intracellular protein transport, nucleocytoplasmic transport, apoptosis, response to oxidative stress, mitochondrion organization, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, SMAD protein nuclear translocation, aging, behavior, learning or memory, learning, circadian rhythm, protein localization, cell death, positive regulation of cell proliferation, negative regulation of cell proliferation, apoptotic mitochondrial changes, cellular response to starvation, response to mechanical stimulus, response to bacterium,response to abiotic stimulus, positive regulation of biosynthetic process, response to extracellular stimulus, response to organic substance, response to inorganic substance, positive regulation of macromolecule biosynthetic process,negative regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process,negative regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, positive regulation of cell death, programmed cell death, response to organic cyclic substance, protein transport, death, protein import, regulation of phosphate metabolic process, cellular homeostasis, epithelial cell differentiation, positive regulation of cellular biosynthetic process, regulation of protein modification process, negative regulation of protein modification process, response to nutrient levels, cellular response to extracellular stimulus,cellular response to nutrient levels, regulation of protein amino acid autophosphorylation, negative regulation of protein amino acid autophosphorylation, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, response to lipopolysaccharide, protein localization in organelle, cellular response to stress, response to cytokine stimulus, protein localization in nucleus, cellular protein localization, leading edge cell differentiation, regulation of cell proliferation, regulation of phosphorylation, negative regulation of phosphorylation,regulation of membrane potential, response to drug, response to hydrogen peroxide, homeostatic process, response to starvation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of neuron apoptosis, positive regulation of neuron apoptosis,establishment of protein localization, regulation of transcription, positive regulation of cell differentiation, regulation of myeloid cell differentiation, positive regulation of myeloid cell differentiation, regulation of monocyte differentiation,positive regulation of monocyte differentiation, positive regulation of DNA replication, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, intracellular transport, rhythmic process, blood vessel morphogenesis, regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation,chemical homeostasis, ion homeostasis, neurological system process, cognition, regulation of DNA metabolic process,positive regulation of DNA metabolic process, positive regulation of developmental process, nuclear transport, nuclear import, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process,negative regulation of protein metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, cellular response to potassium ion starvation, response to cAMP, regulation of cell cycle, membrane depolarization, cellular chemical homeostasis, SMAD protein signal transduction, epithelium development, cellular macromolecule localization.

纯化

Protein A