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Bad (13M8) Rabbit Monoclonal Antibody  Cite:0    分享
抗体类满2送1  

货号： IM68837
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  • 种属：H，M，R
  • 用途：WB，ELISA，IP，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM68837
  • 别名
    BAD;BBC6;BCL2L8;Bcl2 antagonist of cell death;BAD;Bcl-2-binding component 6;Bcl-2-like protein 8;Bcl2-L-8;Bcl-XL/Bcl-2-associated death promoter
  • 产品名称
    Bad (13M8) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 蛋白名称
    BAD
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • Human Gene ID
    572
  • Human Swissprot No.
    Q92934
  • Mouse Gene ID
    12015
  • Mouse Swissprot No.
    Q61337
  • Rat Gene ID
    64639
  • Rat Swissprot No.
    O35147
  • 稀释度
    IHC-P 1:200-1:1000,WB 1:1000-1:5000,IF-P/IF-F/IF-ICC 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200
  • 参考分子量
    23kDa
  • 预测分子量
    18kDa
  • 序列
    Bcl2 antagonist of cell death
  • 宿主
    Rabbit
  • 同种型
    Monoclonal, rabbit, IgG, Kappa
  • 背景介绍
    The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008].
  • 信号通路
    ErbB_HER;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;VEGF;Focal adhesion;Neurotrophin;Insulin_Receptor;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Pathways in cancer;Colorectal cancer;Pancreatic cancer;Endometrial cancer;Prostate cancer;Melanoma;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer.
  • 功能
    domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.,online information:Bcl 2-associated death promoter entry,PTM:Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation.,similarity:Belongs to the Bcl-2 family.,subcellular location:Upon phosphorylation, locates to the cytoplasm.,subunit:Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins.,tissue specificity:Expressed in a wide variety of tissues.
  • 纯化
    Protein A
储存与保存

1.保存：-20℃

2.有效期：1年

注意事项

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