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phospho-MYL12B (Ser20) Rabbit pAb  Cite:0    分享

货号： IM72031
复制产品信息
  • 种属：H，M，R，Dg，Pg，Rab，Cow，Sheep
  • 用途：WB，IF，IHC-P，IHC-F
规格:
50μl 100μl
单位:
支
单价:￥1300.00
产品简介
储存与保存
注意事项
产品简介
  • 货期
    IM72031
  • 英文名称
    phospho-MYL12B (Ser20) Rabbit pAb
  • 别名
    Mylc2b(phospho S20); p-b(phospho S20); ML12B_HUMAN; MLC-2; MLC-2a; MLC-B; MLC20; MRLC2; MYL12B; MYLC2B; Myosin light chain 12B regulatory; Myosin regulatory light chain 12B; myosin regulatory light chain 2; Myosin regulatory light chain 2-B; myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain MRLC2; myosin, light chain 12B, regulatory; OTTHUMP00000162244; OTTHUMP00000165806; OTTHUMP00000165807; OTTHUMP00000165808; SHUJUN-1; smooth muscle isoform.
  • 产品类型
    磷酸化抗体
  • 抗体来源
    Rabbit
  • 克隆类型
    Polyclonal
  • 交叉反应
    predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog
  • 产品应用
    WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
  • 理论分子量
    18 kDa
  • 细胞定位
    细胞浆
  • 性状
    Liquid
  • 浓度
    1mg/ml
  • 免疫原
    KLH conjugated synthesised phosphopeptide derived from human Mylc2b around the phosphorylation site of Ser20: AT(p-S)NV
  • 亚型
    IgG
  • 纯化方法
    affinity purified by Protein A
  • 缓冲液
    0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
  • 产品介绍
    The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
  • Function
    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
  • Tissue Specificity
    Ubiquitously expressed in various hematopoietic cells.
  • Post-translational modifications
    Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment.
  • Similarity
    Contains 3 EF-hand domains.
  • SWISS
    O14950
  • Gene ID
    103910
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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